MCQs on Uveitis
1. The matching of the following diseases and their HLA association are true:
a. sympathetic ophthalmitis      HLA-A11

b. par planitis    HLA-DR2

c. cicatricial pemphigoid     HLA-B5

d. Posner-Schlosmann syndrome     HLA-BW5

e. Vogt-Koyanagi-Harada     HLA-B22


2. Severe vitritis is a feature of:

a. cytomegalovirus retinitis

b. serpigionous choroidpathy

c. presumed ocular histoplasmosis

d. acutre retinal necrosis

e. toxoplasma retinochoroidopathy


3. In ocular toxocarisis:

a. a history of visceral larva migrans is always present

b. examination of the patient's stool is useful in diagnosing
    the disease

c. bilateral ocular involvement should make one doubt the
    accuracy of the diagnosis

d. ultrasound of the granuloma typically shows calcification

e. oral thiabendazole is useful


4.In juvenile chronic arthritis-related uveitis:

a. the uveitis is usually granulomatous

b. the eyes are typically white

c. the uveitis usually precedes arthritis

d. it is associated with positive rheumatoid factor

e. cystoid macular oedema is an important cause of poor


5. The following are true with regard to cataract in juvenile chronic arthritis:

a. cataract should not be performed before the patients is
    8 year-old

b. operation should be performed only when the anterior
    chamber is free of flare

c. removal of the cataract should be combined with
    anterior vitrectomy

d. hypotony is a known post-operative complication in
    these patients

e. only heparin-coated intraocular lens should be


6. The following are true about cytomegaloviral retinitis:

a. it is rarely seen in patients with a CD 4+ counts of
    more than 50 cells/ul

b. it causes full thickness retinal necrosis

c. frosted branch retinitis is a known clinical feature

d. spontaneous resolution in about 30% of patients
    without treatment

e. anti-CMV antibody is useful for diagnosis


7. In the treatment of CMV retinitis:

a. ganciclovir, foscanet and cidofovir are all virostatic

b. ganciclovir causes bone marrow suppression

c. foscanet is associated with renal impairment

d. cidofovir is associated with hepatic dysfunction

e. recurrent CMV retinitis is rare in patients on a
    maintenance dose of ganciclovir, foscanet or cidofovir


8.True statements about HAART (highly active anti-retroviral therapy) include:

a. it reduces the recurrent rate of CMV retinitis

b. it is useful in maintaining a high level of CD 4+ counts

c. it is useful in treating acute retinal necrosis

d. it causes increased vitritis

e. there is an increased risk of cystoid macular oedema


9. In AIDS patients with toxoplasma retinitis:

a. brain abscess occurs in 40% of cases

b. the retinitis is more severe than immunocompetent

c. treatment is only needed in patients with impaired vision

d. retinal detachment is a common cause of visual loss

e. steroid is contraindicated


10. A pregnant woman develops toxoplasmosis in her first trimester of pregnancy. The following are true:

a. there is a 40% chance of the fetus acquiring the infection

b. subsequent offsprings are at risk of infections

c. the Ig M antibody will be raised

d. abortion is advised due to the high risk of fetal

e. sulphadiazine is the preferred treatment than clindamycin


11. True statements about pars planitis include:

a. it is associated with multiple sclerosis in 5% of cases

b. sheathing of the vein is caused by perivascular cuffing
    of lymphocytes

c. snowbanking is the result of hard exudate

d. vitreous balls are composed of epitheloid cells and
    multinucleated giant cells

e. vitreous haemorrhage is the most common cause of
    visual loss


12. A 20 year-old man complains of decreased right vision. Four weeks earlier, he had undergone an extensive bowel operation for Crohn's disease and had received hyperalimentationa dn intravenous antibiotics since the operation. On fundal examination, a fluffy white choroidal lession is seen near the macula. There is minimal vitritis. The following are true about the organisms most likely to be responsible for this condition:

a. culture of the blood is usually positive

b. although commonly seen in the respiratory tract, it
    rarely causes pneumonia

c. this organism will grow on the Sabouraud's culture
    within 48 hours

d. the organism rarely invade the retina

e. intravenous vancomycin is the treatment of choice


13. In serpiginous choroiditis:

a. there is loss of retinal pigment epithelium and the choroid

b. the lesion typically begins near the optic disc

c. visual loss is caused chiefly by cystoid macular oedema

d. fluorescein angiography in the acute phase reveals early
    hyperfluorescence of the lesions

e. systemic cyclosporine is the treatment of choice


14. True statements about APMPPE (acute posterior multifocal placoid pigment epitheliopathy)

a. females are more commonly affected than males

b. recurrence does not occur

c. in the later phase of the fluorescein angiography, the
    lesions appears hyperfluorescent

d. pigmentary disturbance is common in the recovery

e. most patients maintain normal vision on recovery


15. The following drugs are known to cause anterior uveitis:

a. topical alphagan

b. rifabutin

c. rifampicin

d. digoxin

e. alpha-chymotrypsin

16. In Schwartz's syndrome:

a. there is raised intraocular pressure

b. the underlying cause is rhegmatogenous retinal

c. granulomatous uveitis is a feature

d. there is forward movement of the lens-iris diaphragm

e. macular oedema is a main cause of visual loss

17. In Fuch's heterochromic cyclitis:

a. Koeppe's nodules are seen

b. abnormal vessels are seen bridging the angle of the
    trabecular meshwork

c. cataract is seen in 50% of the cases

d. glaucoma is seen in 15% of the cases

e. there is an increased vitreous loss during

18. Posner-Schlossman syndrome:

a.  is painless

b. does not cause glaucomatous field loss

c. is associated with hypopyon in the majority of cases

d. is a self-limiting condition

e. should be treated with systemic steroid

19.The following immunosupprassants and their side-effects are true:

a. cyclophophamide - haemorrhagic cystitis

b. cyclosporine - bone marrow dysplasia

c. azathioprine - nephrotoxicity

d. methotrexate - hepatic fibrosis

e. tacrolimus (FK506) - hyperglycaemia

20. A 25 year-old man from the Middle East complains of blurred right vision. On examination, he was found to have a small hypopyon in the right anterior chamber. Posterior segment of the right eye reveals sheathing of the blood vessels with retinal haemorrhages. He gave a past history of painful lesions in his mouth and his genitals. The following are true about this condition:

a. histopathology of the painful lesion reveals
    pathognomonic feature

b. puncturing the skin with an hypodermic needle may be
    useful in diagnosis

c. the posterior segment pathology is caused by
    inflammation of the retina and choroid

d. oral steroid alone is usually effective in preventing
    relapse of the ocular inflammation

e. unless treated aggressively, the ocular inflammation will
    become chronic


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