Fly mushroom (Amanita muscaria) contains muscarine which
making it poisonous. The infusions of the mushroom are used 
as intoxicating drink in Siberia. Muscarine was first isolated in
1869. Topical application causes miosis, ciliary muscle 
contraction and lacrimation. Ophthalmic use of muscarine 
never becomes popular becuase of the difficulty of isolating
the alkaloid in it pure form and also the highly toxic systemic