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Fly mushroom
(Amanita
muscaria) contains muscarine which
making it poisonous. The infusions of the mushroom are
used
as intoxicating drink in Siberia. Muscarine was first
isolated in
1869. Topical application causes miosis, ciliary muscle
contraction and lacrimation. Ophthalmic use of muscarine
never becomes popular becuase of the difficulty of isolating
the alkaloid in it pure form and also the highly toxic
systemic
effects. |
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