Persistent hyperplastic primary vitreous (PHPV)
This is a rare unilateral condition. Most cases seen in the 
examination will be of the less severe form. Less commonly 
you may have a patient with leukocoria and microphthalmos.

The picture seen here is of the posterior type of PHPV. The 
optic disc contains dense, white fibrous tissue extending towards 
the ora serrata (usually inferiorly). The retinal vessels are distorted 
as they emerge from the optic disc.

Further examination:

  • posterior PHPV may resemble retinopathy of prematurity 

  • with dragged disc. In retinopathy of prematurity, a ridge 
    is usually seen in the periphery
  • the patient may have microphthalmos ± esotropia


1. Which conditions may simulate PHPV?

2. What are the complications of PHPV?

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