Retroillumination in aniridia showing absence 
of iris, the edge of the lens is clearly visible.

Direct illumination of an eye
with aniridia.

Direct illumination of a normal 
eye with dark iris for comparison

The patient has photophobia (may be wearing sun-glasses) and nystgmus (usually pendular type). The iris are 
completely or rudimentary. The edges of the lens are clearly visible. There may be cataract with or without 
subluxation. The cornea may contain pannus and dermoid.

Tell the examiner that:

  • you like to examine the fundus for macular hypoplasia or glaucomatous disc changes.
  • examine the flank for nephrectomy scar for Wilm's tumour (Miller's syndrome).


1. What is the significane of chromosome 11 in aniridia?

2. What is the mechanism of glaucoma in aniridia?


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