Test 13  (uveitis) 

1. The following are true about TINU (tubulointerstitial nephritis 
     uveitis) syndrome:

a. the median age is 15 years of age.

b. females are more frequently affected than males.

c. sarcoidosis is the most common cause 

d. the uveitis typically occurs before the renal problems

e. the most common type of uveitis in TINU syndrome 
    is bilateral anterior uveitis

Answera.T   b.T  c.F  d.F e.T
TINU syndrome typically affects young females.
It is a disease of exclusion. Sarcoidosis in particular needs to be excluded as a cause of uveitis and acute tubulointerstitial nephritis.
The uveitis may develop before, after or simultaneously as the renal problems.

2. The following are true about  TINU syndrome:

a. ibuprofen is associated with TINUS

b. the uveitis must occur within 12 months of the acute 
    interstitial nephritis.

c. permanent visual loss occurs in 25% of patients

d. the renal lesion is characterized by T-cell infiltration.

e. chronic renal disease is uncommon

Answera.T   b.T   c.F   d.T  e.T
NSAIDs are associated with TINU syndrome.
To meet the diagnosis, the uveitis must occur 
within 12 months of the acute interstitial nephritis.
The uveitis usually responds to steroid treatment and visual loss is uncommon.
Chronic renal disease is rare.

3. The following are commonly seen in TINU syndrome:

a. anaemia

b. raised ESR

c. elevated immunoglobulins

d. elevated creatinine

e. increased urinary beta-2-microglobulin.

Answera.T   b.T  c.T  d.T  e.T
Apart from abnormal renal function tests, anaemia, raised ESR, the following are seen:
elevated immunoglobulins
eosinophilia
The urine results show:
proteinuria
elevated urinary beta-2-microglobulin
urinary eosinophilia

4. The following HLA types are associated with increased risk
     of uveitis:

a. HLA B51

b. HLA B7

c. HLA A29

d. HLA DR3

e. HLA DR2

Answera.T  b.T  c.T  d.T  e.T
Apart from HLA B27 which is associated with ankylosing
spondylitis and inflammatory bowel diseases, the
following HLA types also increase the risk:
HLA B51- Behcet's disease
HLA B7   -associated AMPPE
HLA A29 - Birdshot retinochoroidopathy
HLA DR3 - systemic lupus erythematosus
HLA DR2 - multiple sclerosis

5. The following conditions can give rise to both uveitis and 
    erythema nodosum :

a. Crohn's disease

b. Behcet's disease

c. sarcoidosis

d. rheumatoid arthritis

e. systemic lupus erythematosus

Answera.T   b.T  c.T   d.F  e.T

 
 

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