Past MRCOphth April, 2003
1. Mitochondrial Inheritance

2. General questions on chromosome on number of autosomes, X-inactivation, Y chromosome and Sex

3. Homocystinuria

a. biochemical deficiency
b. clinical features: marfanoid habitus, thromboembolic events

3. Enzymopathies

a. Mode of inheritance
b. There is “always” accumulation of substrates
c. Can be caused by partial or complete loss of enzyme activity

4. Corneal deposits occur in:

a. amiodarone
b. corticosteroids
c. phenytoin
d. chloroquine
e. tamoxifen

5. TNF-alpha

a. Produced only by macrophages
b. Exist as soluble and membrane form

6. Macrophages

a. Can ingest PMN
b. Produce IL-1

7. Features of granulomas include:

a. lymphocytes
b. macrophages
c. MNG
d. plasma cells
e. PMN

8. Tumour suppressor genes include

a. p53 
b. APC (Familial adenomatous polyposis)
c. Wnt-1
d. Myc
e. NF-1

9. Retinoblastoma:

a. Most cases inherited as autosomal dominant

10. Drug metabolism is reduced in:

a. smokers 
b. premature infants
c. NAT-deficient individuals
d. alcoholic cirrhosis

11. Decreased oral absorption of tetracycline occurs with concurrent:

a. digoxin
b. iron
c. antacids

12. Features of early inflammation include

a. exudation
b. chemotaxis
c. lymphocytes migration
d. plasma cells
e. macrophages

13. Features of trachoma includes:

a. Follicles in the tarsal/bulbar conjunctiva, ectropion
b. formation of conjunctival epithelial cysts
c. late granulomatous phase
d. viruses
e. can be transmitted by insect bites

14. Adenovirus

a. General questions on structure
b. Is serotype 12 the most common cause of disease

15. Herpes virus

a. Rounded virus
b. Eosinophilic inclusion bodies
c. Can be detected 12 hours after invading the cell

16. Oncogenic viruses

a. Mode of action in inducing neoplastic changes

17. Mast cell stabilisers include: 

a. cromoglycate
b. corticosteroids
c. cyclosporin A
d. 5-HT antagonist

18. Mast cells

a. Cyclic AMP prevents degranulation of vesicles
b. Involved in early stages of Stevens Johnson syndrome

19. Statistics

Usual questions on t tests and chi-square tests

20. Epidemiology

a. Incidence and prevalence: Definition, studies suitable to measure them
b. Retrospective v/s prospective studies
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