Test 47 (pharmacology)
1. Warfarin:
a. the effect of anticoagulation occurs within the first 48 hours
    after the first dose

b. has a half-life of about 12 hours

c. its action is terminated through hepatic metabolism

d. is well absorbed from the gastrointestinal system

e. its action is potentiated by concurrent use of cimetidine

2. 5-fluorouracil:

a. causes megaloblastic anaemia

b. is more effective than mitomycin in reducing fibrosis

c. inhibits thymidylate synthetase

d. is excreted mainly by the renal system

e. is used in the treatment of bowel carcinoma

3. Cefuroxime:

a. inhibits cell wall synthesis

b. has cross-sensitivity with penicillin

c. has good CSF penetration

d. is a third generation cephalosporin

e. is less toxic to the corneal epithelium than gentamicin


4. The following are true about the drugs used in general anaesthetic:
a. suxamethonium causes hyperkalaemia

b. thiopentone is contraindicated in porphyria

c. ketamine increases the sympathetic activity in the nervous 

d. ketamine can reduce the intraocular pressure

e. inhaled isoflurane is mainly metabolized by the liver

5. The following are true about lignocaine:

a. it has a local anaesthetic action lasting for about 6 hours
b. is more active if injected into an inflamed area
c. inhibits the rapid influx of sodium ions into excitable cells
d. its action is prolonged by the concurrent use of adrenaline
e. its onset of action is faster than that of marcaine

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