Test 45   (Pharmacology)
1. The following are true about drug efficacy:
a. a drug A which is effective at 10 micrograms has more 
    efficacy than a drug B which is effective at 10 milligrams

b. it can be demonstrated in a double blind trial comparing the 
    drug with a placebo

c. it is a measure of the amount of drug needed to produce a 
   given effect

d. it is a measure of the drug bioavailability

e. it describes the ability of a drug to produce its therapeutic 

2. With regard to salicylate:

a. it is rapidly exreted by the kidney if the urine is rendered 

b. it is a metabolite of aspirin

c. it causes hyperuricaemia at high doses

d. it potentiates the activity of warfarin

e. it has powerful antipyretic properties

3. The following are true:

a. bioavailability describes the amount of drug which is 
    abosrbed following admistration

b. the volume of distribution is inversely proportional to the 
    clearance of a drug

c. clearance is calculated by dividing the dose adminatered by 
    the area under the time concnetration curve

d. for most drugs the amount eliminated from the plasma is 
    directly proportional to the amount present. 

e. in first order kinetics, the elimination half-life of a drug is 
    indidependent of the dose

4. Cyclosporin A:

a. can only be given orally as it is too toxic to be given 

b. it may be given prophylactically to reduce organ rejection 
    before transplantation

c. causes little bone marrow suppression

d. causes renal impairment

e. acts speficially on cytotoxic T lymphocytes

5. The following antibiotics are bacteriostatic:

a. penicillins

b. erythromycin

c. isoniazid

d. chloramphenicol

e. cotrimoxazole

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