Test 9 (immunology)
1. With regard to interferons:
a. they are produced by B lymphocytes

b. IFNb is produced by cells infected with virus

c. IFNg increases MCH class I and II expression in antigen presenting cell

d. IFNa is produced by fibroblasts

e. they have anti-tumour activity

2. The following are true about interleukins 1 (IL-1):
a. it is produced mainly by the neutrophils

b. it stimulates the proliferation of B and T cells

c. it increases bone production

d. it acts on the hypothalamus to cause fever

e. it increases the production of prostaglandins by T cells

3. With regard to interleukins:

a. IL-2 is produced mainly by CD8+ cells

b. IL-3 stimulates the growth of haemopoietic stem cells

c. IL-4 increases the production of IL-1

d. IL-6 stimulates acute phase protein synthesis

e. IL-6 stimulates abnormal plasma cell clone in multiple myeloma

4. With regard to HLA class 1 antigen:

a. they are expressed on all nucleated cells

b. they are made up of a heavy chain and a light chain

c. they are essential for viral antigen recognition by cytotoxic cells

d. the genes for HLA class 1 molecules are located on chromosome 6 and 15

e. CD4+ cells only recognize antigen presented in association with HLA 
    class I molecules

5. The following are true about lymphocytes:

a. T cells account for 20% of the circulating lymphocytes

b. in the spleen, B cells are found in the periarteriolar areas of white pulp

c. in the lymph nodes, T cells occupy the paracortical area surrounding the 
    germinal centres.

d. B cells but not T cells express surface Ig G

e. B cells undergo maturation in the bone marrow


6. In the complement system;
a. alternative pathway does not rely on antibody

b. classical pathway is best activated by bacterial endotoxin

c. C1 is the first enzyme complex in the classical pathway

d. both the alternative and classical pathway converge at C3 

e. the membrane attack complex is made up of C3a and C5a

7. The following are true about the Fc regions of an immunoglobulins:

a. they can be cleaved from the Fab regions by papain

b. they are responsible for antibody binding

c. they are involved in mast cell binding

d. they are involved in the activation of the complement cascade

e. they determine the ability of the immunoglobulins for transplacental transfer


8. Type IV hypersensitivity responses:
a. are mediated through antibody-antigen complexes

b. typically occur 72 hours after contact with the antigen

c. occur in Kveim's test

d. occur in contact dermatitis

e. occur in hay fever


9. Ig G:
a. has a molecular weight of 150000 

b. is the principal immunoglobulin in secondary immune response

c. is important in mucosal immunity

d. is the most common circulating immunoglobulins in the serum

e. is the only immunoglobulin capable of crossing the placenta


10. The following are true about antigen presenting cells (APC):
a. Langerhan's cells are the antigen presenting cells of the epidermis

b. neutrophils are antigen presenting cells

c. CD8+ cells only recognize antigen presenting cells bearing MHC (major 
    histocompatibility complex) class I 

d. tumour necrosis factor alpha (TNFa  ) can turn endothelial cells into 
    antigen presenting cells

e. they induce clonal T cell proliferation by producing interleukin-1 (IL-1).


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