Test 71     (General pathology)

1. The following conditions are associated increased risk of skin 
    malignancy:

a. Bowen's disease
b. solar keratosis
c. acanthosis nigricans
d. squamous papilloma
e. keratoacanthoma

Answera.T   b.T  c.F   d.F   e.F
Bowen's disease is an in-situ squamous cell carcinoma. Solar keratosis results from sun damage and a small proportion can progress to squamous cell carcinoma.
Acanthosis nigricans is associated with internal malignancy.

2. True statements about keratoacanthoma:

a. it is also called molluscum sebaceum
b. it usually remits spontaneously without leaving scar
c. it is caused by a pox virus
d. central necrosis is uncommon
e. histologically is difficult to distinguish from squamous 
    cell carcinoma

Answera.T   b.F   c.F   d.F   e.T
It remits spontenously but leave behind scar; therefore excision is recommended. Central necrosis can result from rapid growth of the lesion. 

3. Abnromalities of blood clotting occur in:

a. patients taking brufen
b. thalassaemia
c. sickle cell disease
d. Christmas disease
e. von Willebrand's disease

Answera.T   b.F c.F   d.T   e.T
Brufen is a NSAID and therefore has the same effect as aspirin.
Christmas disease is also called haemophilia B and is associated with factor X deficiency.
von Willebrand's disease is caused by a defiency of a factor that form a complex with factor VIII.

4. Berry aneurysms:

a. most often found in the circle of Willis
b. result from atheroma
c. result from abnormalities in the medial wall of the 
    arteries
d. are associated with diabetes mellitus
e. are associated with polycystic renal disease

Answera.T   b.F   c.T   d.F   e.T
Berry aneurysms are congenital disorder most often found in the circle of Willis. They results from weakness int eh medial wall of the arteries. They are associated with polycystic renal disease.

5. The following are true about corneal transplantation in the UK:

a. in the eye bank the whole eye is kept in the culuture 
    medium
b. the cornea is kept at sub-zero temperature in the bank
c. donor eyes older than 65 years of age are rejected
d. specular microscopy is used to count the number of 
    endothelial cells
e. HLA matching is routinely carried out before use

Answera.F   b.F   c.F   d.T   e.F
The corneoscleral button is removed from the donor eye and kept in the culture medium incubated at 37 degrees centregrade. Unlike other organ transplant routine HLA matching is not carried out.

 
 

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