Test 193  (Ocular pharmacology)

1. Drugs that induce transient myopia include:

a. carbonic anhydrase inhibitor

b. sulfonamides

c. tetracycline

d. perchlorperazine

e. steroids

 
Answera.T   b.T  c.T   d.T  e.T
Drugs which cause transient myopia include:
a. sulfonamides
b. tetracycline
c. perchlorperazine
d. steroids
e. carbonic anhydrase inhibitors.

2. Antibiotics that inhibit folic acid synthesis include:

a. ciprofloxacin

b. sulfonamides

c. pyramenthamine

d. clindamycin

e. tetracycline

 

Answera.F  b.T  c.T  d.F  e.F
Sulfonamides blocks folic acid synthesis from paraaminobenzoic acid and pyramenthamine blocks conversion of folic acid to folinic acid. Both are used to treat toxoplasmosis.

 
 

3. Mitomycin C:
 

a. is a naturally occurring antibiotic antimetabolite

b. is active against Gram positive bacteria

c. is active against all cells regardless of cell cycle phase

d. can be used topically to prevent pterygium recurrence 
    following excision

e. can be given intravenously for the treatment of tumour

 
Answer
a.T   b.T  c.T  d.T  e.T
Mitomycin C is an antibiotic antineoplastic with activity against gram-positive bacteria. It is derived from Streptomyces caespitosus. It interrupts DNA replication, halting protein synthesis and mitosis. It is active against all cells regardless of cell cycle phase.

 

. 4. The incidence of retinal detachment is increased with the use of:

a. atropine

b. latanoprost

c. pilocarpine

d. ecothiophate

e. bromonidine

Answer
a.F  b.F  c.T  d.T  e.F
The incidence of retinal detachment is increased in patients on miotics.

5. The effect of topical non-steroidal anti-inflammatory drugs 
    (NSAIDS) include: 

a. increased intraocular pressure

b. maintenance of mydriasis during cataract surgery

c. inhibition of lipoxygenase

d. conjunctival hyperemia

e. bronchospasm

 
Answer
a.T   b.T  c.F  d.F  e.T
Topical NSAIDs do not appear to affect the intraocular pressure. It does not cause mydriasis but help to maintain mydriasis achieved with mydriatic. It inhibits cycloxygenase. It inhibits prostaglandin production that causes conjunctival hyperemia. 
Bronchospasm can occur with topical NSAIDs.

 

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