Test 132  (Pharmacology)
1.  Acyclovir:
a. is a guanine derivative

b. is active against all viruses within the herpes family

c. inhibits RNA gyrase

d. is activated by thymidine kinase within the host cells

e. is more effective against herpes simplex keratitis 
    if given orally than topically

2. Ganclovir:

a. is toxic to kidney

b. causes bone marrow failure

c. is effective against systemic cytomegalovirus infection
    if given orally

d. can be given intravitreally for refractory 
    cytomegalovirus retinitis

e. inhibits DNA polymerase

3. Aminoglycosides:

a. are effective against streptococci

b. require aerobic transport mechanisms to enter 
    the bacterial wall

c. act on messenger RNA

d. are not effectively against systemic infection if
    given orally

e. cause retinal necrosis with intravitreal injection

4. Chloramphenicol:

a. inhibits cell wall synthesis

b. is active against Haemophilus and Neisseria

c. causes ototoxicity

d. causes aplastic anaemia

e. of the topical form should not be given to children 
    under 10 years of age

5. Sulphonamides:

a. inhibit the conversion of para-aminobenzoic acid 
    to folate.

b. are bactericidal

c. are slow-acting 

d. can cause folate deficiency if taken for more than 
    two months

e. are a known cause of  Steven-Johnson's syndrome

More MCQs