Test 131  (Pharmacology)
1.  Metformin:
a. is a biguanide

b. can cause lactic acidosis

c. causes anorexia and weight loss

d. causes hypoglycaemia in non-diabetic patient

e. is contraindicated in renal failure

2. Carbimazole:

a. decreases thyroid hormone synthesis

b. inhibits peripheral conversion of T4 to T3

c. causes neutropenia

d. should be stopped if causes rashes

e. decreases TSH production

3. Chronic administration of glucocorticoids results in:

a. hypertension

b. hyperkalaemia

c. nuclear sclerosis

d. proximal myopathy

e. ocular hypertension

4. Adverse effects of cyclosporin include:

a. tremor

b. nephrotoxicity

c. hirsutism

d. hypokalaemia

e. nausea and gastrointestinal disturbance

5. Corticosteroid inhibits:

a. histamine release

b. leukotriene C4 and D4 synthesis

c. platelet thromboxane A2 synthesis

d. neutrophil production

e. lipocortin production 

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