Test 113  (Pharmacology)
1. The following are true about drugs with a high first-pass effect: 
a. they have low bioavailability

b. they are excreted unchanged by the kidneys

c. their levels in the serum are increased in the presence 
    of hepatic failure

d. they are poorly absorbed 

e. they have a high extraction ratio

2. The blood brain barrier is readily permeable to:
a. strong acids

b. weak bases

c. highly water-soluble drugs

d. lipophilic drugs

e. adrenaline

3. The following are true about tetracycline:
a. its absorption is reduced by food

b. it should be avoided in patient with renal failure

c. it is extensively metabolised by the liver

d. it reduces the efficacy of oral contraceptives 
e. it reduces the anti-coagulant effect of warfarin

4. Ketoconazole:
a. can be used both systemically and topically

b. blocks the demethylation of lanosterol to ergosterol 
    in fungal cells

c. causes renal toxicity

d. inhibits P450 enzymes

e. inhibits the synthesis of steroid enzyme in human at 
    high doses

5. Retinopathy occurs with the following drugs:

a. desferrioxamine

b. vigabatrin

c. ethambutol

d. amiodarone

e. tacrolimus

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