Test 110   (Pharmacology)
1. The following are true about local anaesthetics: 
a. they are weak bases

b. they are either aminoesters or aminoamides

c. they act faster on myelinated fibres than 
    non-myelinated nerve fibres

d. they cause both sensory and motor paralysis

e. the potency and duration are increased by increasing 
    the lipophilia of the compounds

2. The following are true about the local anaesthetics:
a. they are hydrolysed by plasma cholinesterase

b. they are degraded by hepatic enzymes

c. concurrent use of adrenaline increases the duration of action 

d. inadvertent intravascular injection of local anaesthetics can result in respiratory arrest

e. the plasma levels of local anaesthetics are higher in patients taking pilocarpine.

3. The corneal penetration of a topically applied drug:
a. is increased if the epithelium is removed

b. is increased if the intraocular pressure is reduced

c. is increased if the tear production is increased

d. is decreased if the blink rate is increased

e. is decreased if the drug is made more hydrophilic

4. With regard to carbonic anhydrase inhibitors:
a. they inhibit carbonic anhydrase isoenzyme II

b. they have an additive effect when use with beta 

c. systemic side effects do not occur with topical carbonic 
    anhydrase inhibitors.

d. topical dorzolamide has a better corneal penetration 
    than topical acetazolamide

e. dorzolamide possess ampholytic character

5. FK 506:

a. is derived from fungus

b. selectively inhibits the function of B cell lymphocytes 

c. decreases antibody production to T-cell dependent 

c. is 100 times more potent than cyclosporin A

d. is used in preventing allograft rejection

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